SGK3 (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All SGK3 reagents are produced in house and quality controlled, including 15 SGK3 Gene, 1 SGK3 Lysate, 1 SGK3 Protein. All SGK3 reagents are ready to use.

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SGK3 分子背景

Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein which belongs to theprotein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains oneAGC-kinase C-terminal domain, oneprotein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-32) and the other in the C-terminal regulatory region (Ser-486), is needed to be phosphorylated for its full activation. SGK3 is expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. SGK3 is involved in the activation of potassium channels. It mediates cell IL-3-dependent survival signals. SGK3 participates in the regulation of HERG by increasing HERG protein abundance in the plasma membrane and may thus modify the duration of the cardiac action potential. SGK3 is also a very important and characteristic molecule that plays a critical role in both hair follicle morphogenesis and hair cycling.

SGK3 参考文献

  • Friedrich,B. et al., 2003, Pflugers Arch. 445 (6):693-6.
  • Shojaiefard,M. et al., 2005, Biochem Biophys Res Commun. 334 (3): 742 - 6.
  • Maier,G. et al., 2006, Cell Physiol Biochem. 18 (4-5):177-86.
  • Okada,T. et al., 2006, Am J Pathol. 168 (4):1119-33.
  • Mauro,T.M. et al., 2009, FASEB J  23 (9):3193-202.