Anti-SIGNR1 Antibody

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Anti-SIGNR1 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-SIGNR1 Antibody
经验证的应用
FCM,ICC/IF,IF
交叉反应
Reacts with: Mouse
特异性
Mouse SIGNR1
免疫原
Recombinant Mouse SIGNR1 / CD209b protein (Catalog#50486-M07H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIGNR1 / CD209b (rM SIGNR1 / CD209b; Catalog#50486-M07H; NP_081248.2; Gln74-Gly325).
来源
Monoclonal Rabbit IgG Clone #143
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SIGNR1 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ICC-IF 1:20-1:100
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SIGNR1 Antibody (Rabbit Monoclonal 抗体) 图片

Immunofluorescence staining of mouse CD209B in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse CD209B monoclonal antibody (1:60) at 37℃ 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green).
Flow cytometric analysis of Mouse CD209b expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse CD209b, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-SIGNR1 Antibody: 别称

Anti-1810030I22Rik Antibody; Anti-DC-SIGNR1 Antibody; Anti-mSIGNR1 Antibody; Anti-OtB7 Antibody; Anti-SIGNR1 Antibody

SIGNR1 背景信息

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD29b, also known as SIGNR1, is a C-type lectin receptor. CD29b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD29b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD29b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.
全称
CD209b antigen
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Park JY, et al. (2009) The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumonia. Neuroscience Letters. 450 (3): 246-51.
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