Anti-SOX2 Antibody

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Anti-SOX2 Antibody (Rabbit Polyclonal 抗体) 产品信息

Anti-SOX2 Antibody
Reacts with: Human, Mouse
Human SOX2
A synthetic peptide corresponding to the N-terminus of the Human Sox2
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human Sox2, and purified by antigen affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SOX2 Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:2000
IHC-P 1:500-1:2000
ICC-IF 1:300-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SOX2 Antibody (Rabbit Polyclonal 抗体) 图片

Immunochemical staining SOX2 in human trachea with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Immunochemical staining SOX2 in mouse lung with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.

Anti- rabbit polyclonal antibody at 1:500 dilution

Lane A: HESS9 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:34 kDa

Observed band size:37 kDa

(We are unsure as to the identity of these extra bands.)

Immunofluorescence staining of SOX2 in HESS9 cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human SOX2 polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®594-conjugated Goat Anti-rabbit IgG secondary antibody (red), counterstained with DAPI (blue) and Alexa Fluor®488-conjugated anti-tubulin antibody (green). Positive staining was localized to nucleus.

Anti-SOX2 Antibody: 别称

Anti-ANOP3 Antibody; Anti-MCOPS3 Antibody

SOX2 背景信息

SOX2, also known as ANOP3, is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26. SOX2 is critical for early embryogenesis and for embryonic stem cell pluripotency. It keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Defects in SOX2 can cause microphthalmia, syndromic, 3. A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
SRY (sex determining region Y)-box 2
  • Lu Y, et al., 2010, PLoS ONE. 5(6): e11022.
  • Gontan C, et al., 2008, Dev. Biol. 317 (1): 296-309.
  • Shi W, et al., 2006, J. Biol. Chem. 281 (33): 23319-25.
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