Anti-PD-1 Antibody (HRP)

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Anti-PD-1 Antibody (HRP) (Mouse Monoclonal 抗体) 产品信息

产品名称
Anti-PD-1 Antibody (HRP)
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human PD-1
免疫原
Recombinant Human PD1 / PDCD1 / CD279 Protein (Catalog#10377-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PD1 / PDCD1 / CD279 (rh PD1 / PDCD1 / CD279; Catalog#10377-H08H; NP_005009.2; Met1-Gln167). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP).
来源
Monoclonal Mouse IgG2a Clone #07
纯化
Protein A
缓冲液
PBS, 50 % HRP-Protector, pH 7.4
偶联物
HRP
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!

Anti-PD-1 Antibody (HRP) (Mouse Monoclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 0.1-1 μg/ml
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-PD-1 Antibody (HRP): 别称

Anti-CD279 Antibody; Anti-hPD-1 Antibody; Anti-hPD-l Antibody; Anti-hSLE1 Antibody; Anti-PD-1 Antibody; Anti-PD1 Antibody; Anti-SLEB2 Antibody

PD-1 背景信息

Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-1 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
全称
programmed cell death 1
参考文献
  • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
  • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
  • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
  • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
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