Anti-CD20 Antibody, Rabbit Polyclonal

1/2
Price:
Size:
Number:

Anti-CD20 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-CD20 Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Ferret
特异性
Ferret CD20
免疫原
Recombinant Ferret CD20 / MS4A1 protein (Catalog#60004-F08H)
制备方法
Produced in rabbits immunized with purified, recombinant Ferret CD20 / MS4A1 (rF CD20 / MS4A1; Catalog#60004-F08H; Glu 213-Pro 297). CD20 / MS4A1 specific IgG was purified by Ferret CD20 / MS4A1 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD20 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:5000-1:20000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD20 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of ferret CD20 in ferret spleen with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).
Immunochemical staining of ferret CD20 in ferret colon with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).

CD20 背景信息

CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed in all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells are usually in the normal range but can be very low.
全称
membrane-spanning 4-domains, subfamily A, member 1
研究领域
参考文献
  • Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
  • Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
  • Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后 U.S.A.