Anti-FGFR2 Antibody, Mouse Monoclonal

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Anti-FGFR2 Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-FGFR2 Antibody, Mouse Monoclonal
经验证的应用
ELISA(Det)
交叉反应
Reacts with: Human
特异性
Human FGFR2
免疫原
Recombinant Human FGFR2 Protein (Catalog#10824-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FGFR2 (rh FGFR2; Catalog#10824-H08H; NP_000132.3; Met1-Glu377). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Clone #02
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-FGFR2 Antibody, Mouse Monoclonal 经验证的应用

Notes
ELISA(Det): This antibody will detect Human FGFR2 / CD332 in ELISA pair set (Catalog: # SEK10824). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10824-MM10T).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-FGFR2 Antibody, Mouse Monoclonal: 别称

Anti-BBDS Antibody; Anti-BEK Antibody; Anti-BFR-1 Antibody; Anti-CD332 Antibody; Anti-CEK3 Antibody; Anti-CFD1 Antibody; Anti-ECT1 Antibody; Anti-JWS Antibody; Anti-K-SAM Antibody; Anti-KGFR Antibody; Anti-TK14 Antibody; Anti-TK25 Antibody

FGFR2 背景信息

FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.
全称
fibroblast growth factor receptor 2
参考文献
  • Marie PJ, et al. (2003) Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histol. 17(3):877-85.
  • Park WJ, et al. (1996) Novel FGFR2 mutations in Crouzon and Jackson-Weiss syndromes show allelic heterogeneity and phenotypic variability. Hum Mol Genet. 4(7):1229-33.
  • Orr-Urtreger A, et al. (1993) Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol. 158(2):475-86.
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