Recombinant Anti-2B4/CD244 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-2B4/CD244 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-2B4/CD244 Antibody, Rabbit Monoclonal
经验证的应用
ELISA(Det)
交叉反应
Reacts with: Human
特异性
Human 2B4/CD244
免疫原
Recombinant Human 2B4 / CD244 Protein (Catalog#10042-H08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human 2B4 / CD244 (rh 2B4 / CD244; Catalog#10042-H08H; NP_057466.1; Met1-Arg221).
来源
Monoclonal Rabbit IgG Clone #031
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-2B4/CD244 Antibody, Rabbit Monoclonal 经验证的应用

Notes
ELISA(Det): This antibody will detect Human 2B4 / CD244 in ELISA pair set (Catalog: # SEK10042). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10042-R025).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-2B4/CD244 Antibody, Rabbit Monoclonal: 别称

Anti-2B4 Antibody; Anti-NAIL Antibody; Anti-NKR2B4 Antibody; Anti-Nmrk Antibody; Anti-SLAMF4 Antibody

2B4/CD244 背景信息

The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.
全称
CD244 molecule, natural killer cell receptor 2B4
参考文献
  • Nakajima H, et al. (2000) 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 61(1): 39-43.
  • Chuang SS, et al. (2001) 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol. 167(11): 6210-6.
  • McNerney ME, et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 42(4): 489-94.
  • Mathew SO, et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 39(6): 1632-41.
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