Recombinant Anti-AKR1B1 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-AKR1B1 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-AKR1B1 Antibody, Rabbit Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human AKR1B1
免疫原
Recombinant Human AKR1B1 Protein (Catalog#11294-H07E)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human AKR1B1 (rh AKR1B1; Catalog#11294-H07E; P15121; Met1-Phe316).
来源
Monoclonal Rabbit IgG Clone #101
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-AKR1B1 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-AKR1B1 Antibody, Rabbit Monoclonal 图片

Flow cytometric analysis of Human AKR1B1 expression on HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human AKR1B1, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-AKR1B1 Antibody, Rabbit Monoclonal: 别称

Anti-ADR Antibody; Anti-ALDR1 Antibody; Anti-ALR2 Antibody; Anti-AR Antibody; Anti-MGC1804 Antibody

AKR1B1 背景信息

Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily.
全称
aldo-keto reductase family 1, member B1 (aldose reductase)
参考文献
  • Huang SP, et al. (2010) Aldo-Keto Reductases in the Eye. Journal of Ophthalmology. 326 (3): 625-36.
  • Aida K, et al. (2000) Disruption of Aldose Reductase Gene (Akr1b1) Causes Defect in Urinary Concentrating Ability and Divalent Cation Homeostasis. Biochemical and Biophysical Research Communications.277 (2): 281-6.
  • Liao CS, et al. (2009) Regulation of AKR1B1 by thyroid hormone and its receptors. Molecular and Cellular Endocrinology. 307 (1-2): 109-17.
  • Baba SP, et al. (2009) Posttranslational glutathiolation of aldose reductase (AKR1B1): A possible mechanism of protein recovery from S-nitrosylation. Chemico-Biological Interactions. 178 (1-3): 250-8.
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