Anti-ALK4/ACVR1B Antibody, Rabbit Polyclonal

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Anti-ALK4/ACVR1B Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-ALK4/ACVR1B Antibody, Rabbit Polyclonal
经验证的应用
WB,ELISA
交叉反应
Reacts with: Human
特异性
Human ALK4/ACVR1B
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
免疫原
Recombinant Human ALK-4 / ACVR1B protein (Catalog#10583-H08H)
制备方法
Produced in rabbits immunized with purified, recombinant Human ALK-4 / ACVR1B (rh ALK-4 / ACVR1B; Catalog#10583-H08H; NP_004293.1; Met1-Glu126). ALK-4 / ACVR1B specific IgG was purified by Human ALK-4 / ACVR1B affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ALK4/ACVR1B Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:1000
ELISA 1:25000-1:50000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ALK4/ACVR1B Antibody, Rabbit Polyclonal 图片

Anti-ALK4 rabbit polyclonal antibody at 1:500 dilution

Lane A: Mouse kidney Tissue Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:57 kDa

Observed band size:54 kDa

Anti-ALK4/ACVR1B Antibody, Rabbit Polyclonal: 别称

Anti-ACTRIB Antibody; Anti-ACVRLK4 Antibody; Anti-ALK4 Antibody; Anti-SKR2 Antibody

ALK4/ACVR1B 背景信息

ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
全称
activin A receptor, type IB
参考文献
  • Chen Y, et al. (2005) Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. 232(2): 393-8.
  • J. Massagu. (1998) TGF- SIGNAL TRANSDUCTION. Annual Review of Biochemistry. 67: 753-91.
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