Anti-BAX Antibody, Rabbit Polyclonal

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Anti-BAX Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-BAX Antibody, Rabbit Polyclonal
经验证的应用
ICC/IF
交叉反应
Reacts with: Human
特异性
Human BAX
免疫原
A synthetic peptide corresponding to the C-terminus of the Human BAX
制备方法
Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human BAX, and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-BAX Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ICC-IF 1:300-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-BAX Antibody, Rabbit Polyclonal 图片

Immunofluorescence staining of BAX in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human BAX polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytoplasm and nucleus.

Anti-BAX Antibody, Rabbit Polyclonal: 别称

Anti-BCL2L4 Antibody

BAX 背景信息

BCL2 associated X (BAX) is traditionally thought to be regulated by anti-apoptotic BCL-2 family members. BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix alpha5 from alpha6 - the 'latch' from the 'core' domain - among other conformational changes. BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP).
全称
BCL2-associated X protein
Related Pathways
  • Death Receptor Signaling
    Death Receptor Signaling
  • p53 Pathway
    p53 Pathway
  • TNF Signaling
    TNF Signaling
  • AKT Signaling Pathway
    AKT Signaling Pathway
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