Anti-Bim Antibody, Rabbit Polyclonal

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Anti-Bim Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-Bim Antibody, Rabbit Polyclonal
经验证的应用
WB,ELISA
交叉反应
Reacts with: Human
特异性
Human Bim
免疫原
Recombinant Human BCL2L11 / Bim Protein (Catalog#13816-H07E)
制备方法
Produced in rabbits immunized with purified, recombinant Human BCL2L11 / Bim (rh BCL2L11 / Bim; Catalog#13816-H07E; NP_006529.1; Ala2-Arg120). BCL2L11 / Bim specific IgG was purified by Human BCL2L11 / Bim affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Bim Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:1000
ELISA 1:25000-1:50000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Bim Antibody, Rabbit Polyclonal 图片

Anti-BCL2L11 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Whole Cell Lysate

Lane B: K562 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti- Rabbit  IgG H&L (Dylight 800)  at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:22 kDa

Observed band size:24 kDa

(We are unsure as to the identity of these extra bands.)

Anti-Bim Antibody, Rabbit Polyclonal: 别称

Anti-BAM Antibody; Anti-BIM Antibody; Anti-BOD Antibody

Bim 背景信息

BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. BCL2L11 gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
全称
BCL2-like 11 (apoptosis facilitator)
Related Pathways
  • AKT Signaling Pathway
    AKT Signaling Pathway
  • MAPK-Erk Pathway
    MAPK-Erk Pathway
参考文献
  • Day Catherine L. et al., 2004, Biochem J. 377 (3): 597-605.
  • Murray S. et al., 2001, Cytogenet Cell Genet. 92 (3-4): 353.
  • Hsu SY. et al., 1998,Mol Endocrinol. 12 (9): 1432-40.
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