Anti-BMPR1A/ALK-3 Antibody, Rabbit Polyclonal

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Anti-BMPR1A/ALK-3 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-BMPR1A/ALK-3 Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Human
特异性
Human BMPR1A/ALK-3
免疫原
Recombinant Human ALK-3 / BMPR1A protein (Catalog#10446-H08H)
制备方法
Produced in rabbits immunized with purified, recombinant Human ALK-3 / BMPR1A (rh ALK-3 / BMPR1A; Catalog#10446-H08H; NP_004320.2; Met1-Arg152). ALK-3 / BMPR1A specific IgG was purified by Human ALK-3 / BMPR1A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-BMPR1A/ALK-3 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:2500-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-BMPR1A/ALK-3 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of human ALK3 in human breast carcinoma with rabbit polyclonal antibody (1:10000, formalin-fixed paraffin embedded sections).

Anti-BMPR1A/ALK-3 Antibody, Rabbit Polyclonal: 别称

Anti-10q23del Antibody; Anti-ACVRLK3 Antibody; Anti-ALK3 Antibody; Anti-CD292 Antibody; Anti-SKR5 Antibody

BMPR1A/ALK-3 背景信息

Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. The BMP receptors form a subfamily of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. ALK-3/BMPR1A is expressed in the epithelium during branching morphogenesis. Deletion of BMPR1A in the epithelium with an Sftpc-cre transgene leads to dramatic defects in lung development. ALK-3 and ALK-6 share a high degree of homology, yet possess distinct signaling roles. The transforming growth factor (TGF)-beta type III receptor (TbetaRIII) enhanced both ALK-3 and ALK-6 signaling. TbetaRIII associated with ALK-3 primarily through their extracellular domains, whereas its interaction with ALK-6 required both the extracellular and cytoplasmic domains. ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK-3 was specifically deficient in expressing TGFbeta2, an established paracrine mediator of cushion morphogenesis. Hence, ALK-3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis.
全称
bone morphogenetic protein receptor, type IA
参考文献
  • Gaussin V, et al. (2002) Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A. 99(5): 2878-83.
  • Eblaghie MC, et al. (2006) Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol. 291(1): 67-82.
  • Sun J, et al. (2007) Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect. Biochem Biophys Res Commun. 360(1): 238-43.
  • Lee NY, et al. (2009) The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. Mol Biol Cell. 20(20): 4362-70.
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