Anti-BMPRIB Antibody, Mouse Monoclonal

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Anti-BMPRIB Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-BMPRIB Antibody, Mouse Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human BMPRIB
No cross-reactivity in ELISA with
Insect cell lysate
免疫原
Recombinant Human ALK-6 / BMPR1B protein (Catalog#10460-H20B)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ALK-6 / BMPR1B (rh ALK-6 / BMPR1B; Catalog#10460-H20B; NP_001194.1; Arg149-Leu502). The IgG fraction of the cell culture supernatant was purified by Protein A affinity.
来源
Monoclonal Mouse IgG1 Clone #06
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-BMPRIB Antibody, Mouse Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-BMPRIB Antibody, Mouse Monoclonal: 别称

Anti-ALK-6 Antibody; Anti-ALK6 Antibody; Anti-CDw293 Antibody

BMPRIB 背景信息

BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective transducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.
全称
bone morphogenetic protein receptor, type IB
参考文献
  • Ide H, et al. (1998) Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23--q24 byin situ hybridization and radiation hybrid map ping. Cytogenet. Cell Genet. 81(3-4): 285-6.
  • Mishina Y, et al. (2004) Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J Biol Chem. 279(26): 27560-6.
  • Yoon BS, et al. (2005) Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci. 102(14): 5062-7.
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