Recombinant Anti-c-MET Antibody, Rabbit Monoclonal

RRID Number: AB_2860210
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-c-MET Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-c-MET Antibody, Rabbit Monoclonal
经验证的应用
ELISA,FCM
交叉反应
Reacts with: Human
特异性
Human c-MET
免疫原
Recombinant Human c-MET / HGFR protein (Catalog#10692-H03H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human c-MET / HGFR (rh c-MET / HGFR; Catalog#10692-H03H; NP_000236.2; Met1-Thr932).
来源
Monoclonal Rabbit IgG Clone #243
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-c-MET Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-c-MET Antibody, Rabbit Monoclonal 图片

Flow cytometric analysis of Human C-Met(HGFR) expression on HepG2 cells. Cells were stained with purified anti-Human C-Met(HGFR), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-c-MET Antibody, Rabbit Monoclonal: 别称

Anti-AUTS9 Antibody; Anti-c-Met Antibody; Anti-DFNB97 Antibody; Anti-HGFR Antibody; Anti-RCCP2 Antibody

c-MET 背景信息

Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
全称
MET proto-oncogene, receptor tyrosine kinase
参考文献
  • McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
  • Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
  • Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
  • Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.
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