Recombinant Human Cbl-c / CBL-3 protein (Catalog#15659-H20B)
Produced in rabbits immunized with purified, recombinant Human Cbl-c / CBL-3 (rh Cbl-c / CBL-3; Catalog#15659-H20B; AAH28915.1; Met1-Ala474). Cbl-c / CBL-3 specific IgG was purified by Human Cbl-c / CBL-3 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-Cbl-c Antibody, Rabbit Polyclonal 经验证的应用
Please Note: Optimal concentrations/dilutions should be determined by the end user.
CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c gene.
Cbl proto-oncogene C, E3 ubiquitin protein ligase
Kim M. et al., 1999, Gene. 239 (1): 145-54.
Courbard JR. et al., 2003, J. Biol. Chem. 277 (47): 45267-75.
Keane MM. et al., 1999, Oncogene. 18 (22): 3365-75.