Anti-CD155/PVR Antibody (FITC), Mouse Monoclonal

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Anti-CD155/PVR Antibody (FITC), Mouse Monoclonal 产品信息

产品名称
Anti-CD155/PVR Antibody (FITC), Mouse Monoclonal
经验证的应用
FCM,ICC/IF
交叉反应
Reacts with: Human
特异性
Human CD155/PVR
免疫原
Recombinant Human CD155 protein (Catalog#10109-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD155 / PVR (rh CD155 / PVR; Catalog#10109-H08H; P15151-1; Met 1-Asn 343) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
来源
Monoclonal Mouse IgG1 Clone #9B8G1H5
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
FITC
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD155/PVR Antibody (FITC), Mouse Monoclonal 经验证的应用

应用 推荐稀释比/用量
ICC-IF 5-20 μg/mL
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD155/PVR Antibody (FITC), Mouse Monoclonal 图片

Profile of CD155 reactivity on HeLa cells analyzed by flow cytometry.
Immunofluorescence staining of Human CD155 in A549 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Mouse anti-Human CD155 monoclonal antibody (FITC-conjugated, 10 µg/ml) at 4℃ overnight, and counterstained with DAPI (blue). Positive staining was localized to plasma membrane.

Anti-CD155/PVR Antibody (FITC), Mouse Monoclonal: 别称

Anti-CD155 Antibody; Anti-HVED Antibody; Anti-Necl-5 Antibody; Anti-NECL5 Antibody; Anti-PVS Antibody; Anti-TAGE4 Antibody

CD155/PVR 背景信息

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
全称
poliovirus receptor
研究领域
参考文献
  • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
  • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
  • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
  • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
  • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
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