Recombinant Anti-CD20 Antibody (PerCP), Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CD20 Antibody (PerCP), Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-CD20 Antibody (PerCP), Rabbit Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human CD20
免疫原
Human CD20 Transfected CHO Cells
制备方法
This antibody was obtained from a rabbit immunized with purified, Human CD20 Transfected CHO Cells and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
来源
Monoclonal Rabbit IgG Clone #001
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PerCP
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Recombinant Anti-CD20 Antibody (PerCP), Rabbit Monoclonal 图片

Profile of anti-CD20 reactivity on peripheral blood lymphocytes analyzed by flow cytometry.

Recombinant Anti-CD20 Antibody (PerCP), Rabbit Monoclonal: 别称

Anti-B1 Antibody; Anti-Bp35 Antibody; Anti-CD20 Antibody; Anti-CVID5 Antibody; Anti-LEU-16 Antibody; Anti-MS4A1 Antibody; Anti-MS4A2 Antibody; Anti-S7 Antibody

CD20 背景信息

CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed in all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells are usually in the normal range but can be very low.
全称
membrane-spanning 4-domains, subfamily A, member 1
研究领域
参考文献
  • Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
  • Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
  • Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.
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