Anti-CD204/MSR1 Antibody, Rabbit Polyclonal

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Anti-CD204/MSR1 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-CD204/MSR1 Antibody, Rabbit Polyclonal
经验证的应用
WB,ELISA
交叉反应
Reacts with: Human
特异性
Human CD204/MSR1
免疫原
Recombinant Human MSR1 / CD204 protein (Catalog#10427-H07H)
制备方法
Produced in rabbits immunized with purified, recombinant Human MSR1 / CD204 (rh MSR1 / CD204; Catalog#10427-H07H; NP_619729.1; Lys77-Leu451). MSR1 / CD204 specific IgG was purified by Human MSR1 / CD204 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD204/MSR1 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:2000
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD204/MSR1 Antibody, Rabbit Polyclonal 图片

Anti-MSR rabbit polyclonal antibody at 1:500 dilution

Lane A: THP1 Whole Cell Lysate

Lane B: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:50 kDa

Observed band size:58 kDa

Anti-CD204/MSR1 Antibody, Rabbit Polyclonal: 别称

Anti-CD204 Antibody; Anti-phSR1 Antibody; Anti-phSR2 Antibody; Anti-SCARA1 Antibody; Anti-SR-A Antibody; Anti-SRA Antibody

CD204/MSR1 背景信息

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low-density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.
全称
macrophage scavenger receptor 1
参考文献
  • Wang L. et al., 2003, Nat Genet. 35 (2): 128-9.
  • Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3.
  • Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103.
  • Sun J. et al., 2006, Prostate. 66 (7): 728-37.
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