Anti-CD27 Antibody (PE), Mouse Monoclonal

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Anti-CD27 Antibody (PE), Mouse Monoclonal 产品信息

产品名称
Anti-CD27 Antibody (PE), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human CD27
免疫原
Recombinant Human CD27 / TNFRSF7 protein (Catalog#10039-H03H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD27 / TNFRSF7 (rh CD27 / TNFRSF7; Catalog#10039-H03H; NP_001233.1; Met 1-Ile 192) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Mouse IgG1 Clone #09
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PE
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD27 Antibody (PE), Mouse Monoclonal 图片

Flow cytometric analysis of anti-human CD27 on human whole blood lymphocytes. Human lymphocytes were stained with PE-anti human CD27-MM09 (solid line) or FITC-Mouse IgG isotype control (dashed line).

Anti-CD27 Antibody (PE), Mouse Monoclonal: 别称

Anti-S152 Antibody; Anti-S152. LPFS2 Antibody; Anti-S152.LPFS2 Antibody; Anti-T14 Antibody; Anti-TNFRSF7 Antibody; Anti-Tp55 Antibody

CD27 背景信息

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.
全称
CD27 molecule
研究领域
参考文献
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
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