Anti-CD300A Antibody, Mouse Monoclonal

1/1
Price:
Size:
Number:

Anti-CD300A Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-CD300A Antibody, Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human CD300A
免疫原
Recombinant Human CD300A Protein (Catalog#12449-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD300A (rh CD300A; Catalog#12449-H08H; Q9UGN4-1; Met1-Gln178). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG1 Clone #01
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD300A Antibody, Mouse Monoclonal 经验证的应用

应用 推荐稀释比/用量
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD300A Antibody, Mouse Monoclonal 图片

Flow cytometric analysis of Human CD300A expression on Human whole blood monocytes. Cells were stained with purified anti-Human CD300A, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes.

Anti-CD300A Antibody, Mouse Monoclonal: 别称

Anti-CLM-8 Antibody; Anti-CMRF-35-H9 Antibody; Anti-CMRF-35H Antibody; Anti-CMRF35-H Antibody; Anti-CMRF35-H9 Antibody; Anti-CMRF35H Antibody; Anti-CMRF35H9 Antibody; Anti-IGSF12 Antibody; Anti-IRC1 Antibody; Anti-IRC1/IRC2 Antibody; Anti-IRC2 Antibody; Anti-IRp60 Antibody

CD300A 背景信息

CMRF35-like molecule 8, also known as CD300 antigen-like family member A, CMRF35-H9, Immunoglobulin superfamily member 12, Inhibitory receptor protein 60, NK inhibitory receptor, CD300a and CMRF35H, is a single-pass type I membrane protein which belongs to the CD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating ( CD300b, CD300e ) and inhibitory members ( CD300a, CD300f ), as well as molecules presenting a negative charge within their transmembrane domain ( CD300c, CD300d ). CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. It contains oneIg-like V-type ( immunoglobulin-like ) domain. CD300A / IGSF12 is an inhibitory receptor that may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs).
全称
CD300a molecule
参考文献
  • Bachelet,I. et al., 2005, J. Immunol. 175:7989-7995.
  • Bachelet,I. et al., 2008, J Immunol. 180 (9):6064-9.
  • Ju,X. et al., 2008, Blood. 112 (4):1184-94.
  • Martínez-Barriocanal,A. et al., 2010, J Biol Chem. 285 (53):41781-94.
  • Lankry,D. et al., 2010, J Immunol. 185 (5):2877-86.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后 U.S.A.