Anti-CR1/CD35 Antibody, Rabbit Polyclonal

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Anti-CR1/CD35 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-CR1/CD35 Antibody, Rabbit Polyclonal
经验证的应用
IHC-P
交叉反应
Reacts with: Human
特异性
Human CR1/CD35
免疫原
A synthetic peptide corresponding to the N-terminus of the human CD35
制备方法
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the human CD35, and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CR1/CD35 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:1000-1:4000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CR1/CD35 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of human CD35 in human tonsil with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human CD35 in human kidney with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).

Anti-CR1/CD35 Antibody, Rabbit Polyclonal: 别称

Anti-C3BR Antibody; Anti-C4BR Antibody; Anti-CD35 Antibody; Anti-KN Antibody; Anti-RP11-57I17.1 Antibody

CR1/CD35 背景信息

Complement receptor type 1 (CR1) is a multi-modular membrane receptor composed of 30 homologous complement control protein modules (CCP) organized in four different functional regions called long homologous repeats (LHR A, B, C, and D). CR1 is a receptor for complement-opsonins C3b and C4b and specifically interacts through pairs of CCP modules located in LHR A, B, and C. Human CR1 plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Lower CR1 expression has been associated with susceptibility to systemic lupus erythematosus (SLE). In contrast, subjects displaying lower CR1 expression are protected against severe manifestations of falciparum malaria. The CR1 gene was shown to be involved in Alzheimer's disease (AD).
全称
complement component 3b/4b receptor 1 (Knops blood group)
参考文献
  • Sandri TL, et al. (2018) Human complement receptor type 1 (cr1) protein levels and genetic variants in chronic chagas disease. Sci Rep 8 (1): 526.
  • Panda AK, et al. (2016) Cr1 exon variants are associated with lowered cr1 expression and increased susceptibility to sle in a plasmodium falciparum endemic population. Lupus Sci Med 3 (1): e000145.
  • Mahmoudi R, et al. (2018) Inherited and acquired decrease in complement receptor 1 (cr1) density on red blood cells associated with high levels of soluble cr1 in alzheimer's disease. Int J Mol Sci 19 (8): 2175.
  • Jacquet M, et al. (2018) C1q and mannose-binding lectin interact with cr1 in the same region on ccp24-25 modules. Front Immunol 9 453.
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