Anti-Cystatin S Antibody, Mouse Monoclonal

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Anti-Cystatin S Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-Cystatin S Antibody, Mouse Monoclonal
经验证的应用
ELISA,ELISA(Cap)
交叉反应
Reacts with: Human
特异性
Human Cystatin S
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
免疫原
Recombinant Human Cystatin S / CST4 Protein (Catalog#11542-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cystatin S / CST4 (rh Cystatin S / CST4; Catalog#11542-H08H; NP_001890.1; Met 1-Ala 141). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG2a Clone #9E2E2
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Cystatin S Antibody, Mouse Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
ELISA(Cap) 1:250-1:2000
Notes
ELISA(Cap): This antibody will detect Human Cystatin S / CST4 in ELISA pair set (Catalog: # SEK11542). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 11542-MM10).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Cystatin S Antibody, Mouse Monoclonal: 别称

Anti-CST4 Antibody; Anti-MGC71923 Antibody

Cystatin S 背景信息

Cystatin-S, also known as Cystatin-4, Salivary acidic protein 1, Cystatin-SA-III and CST4, is a secreted protein which belongs to thecystatin family. Cystatin-4 / CST4 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). It is also expressed in saliva, tears, urine and seminal fluid. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. Cystatin-4 / CST4 strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively. Cystatin-4 / CST4 is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function.
全称
cystatin S
参考文献
  • Bobek L.A., et al.,(1991), Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry. Biochem. J. 278:627-635.
  • Saitoh E., et al., (1992), Characterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes.Agents Actions 38:340-348.
  • Deloukas P., et al.,(2001), The DNA sequence and comparative analysis of human chromosome 20.Nature 414:865-871.
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