Anti-DR4/TRAIL R1 Antibody, Rabbit Polyclonal

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Anti-DR4/TRAIL R1 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-DR4/TRAIL R1 Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human DR4/TRAIL R1
免疫原
Recombinant Human TRAIL R1/CD261/TNFRSF10A Protein (Catalog#10408-H08H)
制备方法
Produced in rabbits immunized with purified, recombinant Human TRAIL R1/CD261/TNFRSF10A (rh TRAIL R1/CD261/TNFRSF10A; Catalog#10408-H08H; NP_003835.2; Met1-Asn239). TRAIL R1/CD261/TNFRSF10A specific IgG was purified by Human TRAIL R1/CD261/TNFRSF10A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-DR4/TRAIL R1 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-DR4/TRAIL R1 Antibody, Rabbit Polyclonal: 别称

Anti-APO2 Antibody; Anti-CD261 Antibody; Anti-DR4 Antibody; Anti-MGC9365 Antibody; Anti-TNFRSF10A Antibody; Anti-TRAILR-1 Antibody; Anti-TRAILR1 Antibody

DR4/TRAIL R1 背景信息

Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.
全称
tumor necrosis factor receptor superfamily member 10a
研究领域
Related Pathways
  • Death Receptor Signaling
    Death Receptor Signaling
参考文献
  • Kimberley FC, et al. (2005) Following a TRAIL: update on a ligand and its five receptors.". Cell Res. 14 (5): 359–72.
  • Schneider P, et al. (1997) Characterization of two receptors for TRAIL.". FEBS Lett. 416 (3): 329–34.
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