Anti-Endoglin/CD105 Antibody (PerCP), Mouse Monoclonal

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Anti-Endoglin/CD105 Antibody (PerCP), Mouse Monoclonal 产品信息

产品名称
Anti-Endoglin/CD105 Antibody (PerCP), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human Endoglin/CD105
免疫原
Recombinant Human Endoglin / CD105 Protein (Catalog#10149-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Endoglin / CD105 (rh Endoglin / CD105 ; Catalog#10149-H08H; NP_001108225.1; Met1-Gly586) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
来源
Monoclonal Mouse IgG2b Clone #13
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PerCP
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-Endoglin/CD105 Antibody (PerCP), Mouse Monoclonal 图片

Flow cytometric analysis of Human CD105 expression on U937 cells. Cells were stained with PerCP-conjugated anti-Human CD105. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-Endoglin/CD105 Antibody (PerCP), Mouse Monoclonal: 别称

Anti-END Antibody; Anti-HHT1 Antibody; Anti-ORW1 Antibody

Endoglin/CD105 背景信息

Endoglin, also known as CD15, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
全称
endoglin
参考文献
  • Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
  • Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
  • Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.
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