Anti-GM-CSF Receptor alpha Antibody (PE), Mouse Monoclonal

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Anti-GM-CSF Receptor alpha Antibody (PE), Mouse Monoclonal 产品信息

产品名称
Anti-GM-CSF Receptor alpha Antibody (PE), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human GM-CSF Receptor alpha
免疫原
Recombinant Human CD116 / GM-CSFR protein (Catalog#10701-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD116 / GM-CSFR (rh CD116 / GM-CSFR; Catalog#10701-H08H; P15509-1; Met1-Gly320) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Mouse IgG1 Clone #03
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PE
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-GM-CSF Receptor alpha Antibody (PE), Mouse Monoclonal 图片

Flow cytometric analysis of anti-human GM-CSFRa(CD116) on human whole blood monocytes. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable monocytes.

Anti-GM-CSF Receptor alpha Antibody (PE), Mouse Monoclonal: 别称

Anti-CD116 Antibody; Anti-CDw116 Antibody; Anti-CSF2R Antibody; Anti-CSF2RAX Antibody; Anti-CSF2RAY Antibody; Anti-CSF2RX Antibody; Anti-CSF2RY Antibody; Anti-GM-CSF-R-alpha Antibody; Anti-GMCSFR Antibody; Anti-GMR Antibody; Anti-SMDP4 Antibody

GM-CSF Receptor alpha 背景信息

CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.
全称
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
参考文献
  • Sjöblom C, et al. (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23.
  • Goldstein JI, et al. (2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16.
  • Saulle E, et al. (2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.
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