Anti-GM-CSF Receptor alpha Antibody, Rabbit Polyclonal

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Anti-GM-CSF Receptor alpha Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-GM-CSF Receptor alpha Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human GM-CSF Receptor alpha
免疫原
Recombinant Human CD116 protein (Catalog#10701-H08H)
制备方法
Produced in rabbits immunized with purified, recombinant Human CD116 / GM-CSFR (rh GM-CSFR; Catalog#10701-H08H; P15509-1; Met 1-Gly 320). Total IgG was purified by Protein A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-GM-CSF Receptor alpha Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-GM-CSF Receptor alpha Antibody, Rabbit Polyclonal: 别称

Anti-CD116 Antibody; Anti-CDw116 Antibody; Anti-CSF2R Antibody; Anti-CSF2RAX Antibody; Anti-CSF2RAY Antibody; Anti-CSF2RX Antibody; Anti-CSF2RY Antibody; Anti-GM-CSF-R-alpha Antibody; Anti-GMCSFR Antibody; Anti-GMR Antibody; Anti-SMDP4 Antibody

GM-CSF Receptor alpha 背景信息

CD116/GM-CSFR has been preferentially associated with M4, M5 subtype of AML but is not specific. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD116/GM-CSFR is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. CD116/GM-CSFR is found in the pseudoautosomal region (PAR) of the X and Y chromosomes.
全称
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
参考文献
  • Sjöblom C, et al. (2002) Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos. Biol Reprod. 67(6): 1817-23.
  • Goldstein JI, et al. (2011) Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 141(1): 208-16.
  • Saulle E, et al. (2009) Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation. Br J Haematol. 145(3): 399-411.
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