Anti-HER3/ERBB3 Antibody (PE)

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Anti-HER3/ERBB3 Antibody (PE) (Mouse Monoclonal 抗体) 产品信息

产品名称
Anti-HER3/ERBB3 Antibody (PE)
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human HER3/ERBB3
免疫原
Recombinant Human ErbB3 / HER3 protein (Catalog#10201-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ErbB3 / HER3 (rh ErbB3 / HER3; Catalog#10201-H08H; NP_001973.2; Met1-Thr643) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Mouse IgG1 Clone #03
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PE
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-HER3/ERBB3 Antibody (PE) (Mouse Monoclonal 抗体) 图片

Flow cytometric analysis of anti-Human ErbB3 on MCF-7 cells.

Anti-HER3/ERBB3 Antibody (PE): 别称

Anti-c-erbB-3 Antibody; Anti-c-erbB3 Antibody; Anti-EEBB3 Antibody; Anti-ErbB-3 Antibody; Anti-erbB3-S Antibody; Anti-HER3 Antibody; Anti-LCCS2 Antibody; Anti-MDA-BF-1 Antibody; Anti-p180-ErbB3 Antibody; Anti-p45-sErbB3 Antibody; Anti-p85-sErbB3 Antibody

HER3/ERBB3 背景信息

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
全称
erb-b2 receptor tyrosine kinase 3
参考文献
  • Kraus M.H., et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197.
  • Plowman G.D., et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909.
  • Katoh M., et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.
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