Anti-IGF1 LR3 Antibody

RRID Number: AB_2860202
EliteRmab®, manufactured by recombinant technology
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Anti-IGF1 LR3 Antibody 产品信息

产品名称
Anti-IGF1 LR3 Antibody
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human IGF1
Has cross-reactivity in ELISA with
Mouse IGF2
No cross-reactivity in ELISA with
Human IGF1R
Human IGF2
Human IGFBP3
Human IGFBP4
Human IGFBP6
免疫原
Recombinant Human IGF1 LR3 protein (Catalog#10598-HNAE)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human IGF1 LR3 (rh IGF1 LR3; Catalog#10598-HNAE; P05019-1; Gly49-Ala118).
来源
Monoclonal Rabbit IgG Clone #023
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IGF1 LR3 Antibody 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IGF1 LR3 Antibody: 别称

Anti-IGF-1 Antibody; Anti-IGF-I Antibody; Anti-IGF1A Antibody; Anti-IGFI Antibody; Anti-IGF‑I Antibody; Anti-MGF Antibody

IGF1 背景信息

IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.
全称
insulin-like growth factor 1 (somatomedin C)
参考文献
  • Jansen M., et al.,(1983), Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature 306:609-611.
  • de Pagter-Holthuizen P., et al., (1986), Organization of the human genes for insulin-like growth factors I and II.FEBS Lett. 195:179-184.
  • le Bouc Y., et al.,(1986), Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.FEBS Lett. 196:108-112.
  • Blockade of sonic hedgehog signaling decreases viability and induces apoptosis in retinoblastoma cells: The key role of the PI3K/Akt pathway
    Author
    Song, Z;Du, Y;Tao, Y;
    Year
    2017
    Journal
    Oncology Letters
    Application
    cell-based(culture)
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