Anti-IL-6R Antibody, Mouse Monoclonal

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Anti-IL-6R Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-IL-6R Antibody, Mouse Monoclonal
经验证的应用
ELISA(Cap)
交叉反应
Reacts with: Human
特异性
Human IL-6R
免疫原
Recombinant Human IL-6R / CD126 protein (Catalog#10398-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL-6R / CD126 (rh IL-6R / CD126; Catalog#10398-H08H; NP_000556.1; Met1-Pro365). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG1 Clone #18
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL-6R Antibody, Mouse Monoclonal 经验证的应用

Notes
ELISA(Cap): This antibody will detect Human IL6R / IL-6R / CD126 in ELISA pair set (Catalog: # SEKA10398). In a sandwich ELISA, it can be used as capture antibody.
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL-6R Antibody, Mouse Monoclonal: 别称

Anti-CD126 Antibody; Anti-gp80 Antibody; Anti-IL-6R Antibody; Anti-IL-6R-1 Antibody; Anti-IL-6RA Antibody; Anti-IL6Q Antibody; Anti-IL6RA Antibody; Anti-IL6RQ Antibody

IL-6R 背景信息

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
全称
interleukin 6 receptor
研究领域
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参考文献
  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
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