Recombinant Anti-IL2RG Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-IL2RG Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-IL2RG Antibody, Rabbit Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human IL2RG
Has cross-reactivity in ELISA with
Human IL2Ra
No cross-reactivity in ELISA with
Human IL1R1
Human IL1R2
Human IL3Ra
Human IL4R
Human IL5Ra
Human IL7R
Mouse IL2Ra
免疫原
Recombinant Human CD132 / IL2RG protein (Catalog#10555-H08B)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD132 / IL2RG (rh CD132 / IL2RG; Catalog#10555-H08B; P31785); Met1-Asn254).
来源
Monoclonal Rabbit IgG Clone #044
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-IL2RG Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-IL2RG Antibody, Rabbit Monoclonal: 别称

Anti-CD132 Antibody; Anti-CIDX Antibody; Anti-IL-2RG Antibody; Anti-IMD4 Antibody; Anti-P64 Antibody; Anti-SCIDX Antibody; Anti-SCIDX1 Antibody

IL2RG 背景信息

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.
全称
interleukin 2 receptor, gamma
Related Pathways
  • Common G-Chain signaling pathway
    Common G-Chain signaling pathway
参考文献
  • Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
  • Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
  • Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.
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