Anti-KAT1/HAT1 Antibody, Rabbit Polyclonal

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Anti-KAT1/HAT1 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-KAT1/HAT1 Antibody, Rabbit Polyclonal
经验证的应用
WB,ICC/IF
交叉反应
Reacts with: Human
Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
特异性
Human KAT1/HAT1
免疫原
A synthetic peptide corresponding to the N-terminus of the Human HAT1
制备方法
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human HAT1, and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-KAT1/HAT1 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:2000
ICC-IF 1:300-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-KAT1/HAT1 Antibody, Rabbit Polyclonal 图片

Immunofluorescence staining of HAT1 in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human HAT1 polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®594-conjugated Goat Anti-rabbit IgG secondary antibody (red). Positive staining was localized to nucleus.

Anti-HAT1 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Whole Cell Lysate

Lane B: K562 Whole Cell Lysate

Lane C: HepG2 Whole Cell Lysate

Lane D: U87MG Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:49 kDa

Observed band size:49 kDa

Anti-KAT1/HAT1 Antibody, Rabbit Polyclonal: 别称

Anti-KAT1 Antibody

KAT1/HAT1 背景信息

HAT1 (Histone Acetyltransferase 1) is a Protein Coding gene. The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. HAT1 can up-regulate cell apoptosis. The dysfunction of apoptosis is one of the factors contributing to lung cancer (LC) growth. Upregulation of HAT1 expression in LCCs can induce LCCs apoptosis, which may be a potential novel therapy for the treatment of LC. KAT8 or HAT1 regulate HBV replication and may be potential drug targets of anti-HBV therapy. HAT1 played an important role in esophageal carcinoma and that it could be a novel EC therapeutic target.
全称
histone acetyltransferase 1
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