Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal

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Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal
经验证的应用
IHC-P,ICC/IF
交叉反应
Reacts with: Human
Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
特异性
Human MEK5/MAP2K5
免疫原
A synthetic peptide corresponding to the N-terminus of the Human MAP2K5
制备方法
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human MAP2K5, and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:100-1:500
ICC-IF 1:300-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal 图片

Immunofluorescence staining of MAP2K5 in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human MAP2K5 polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to nucleus.
Immunochemical staining of human MAP2K5 in human skeletal muscle with rabbit polyclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human MAP2K5 in human heart with rabbit polyclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal: 别称

Anti-HsT17454 Antibody; Anti-MAPKK5 Antibody; Anti-MEK5 Antibody; Anti-PRKMK5 Antibody

MEK5/MAP2K5 背景信息

MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5, also known as MEK5) is a Protein Coding gene. The protein encoded by this gene is a dual-specificity protein kinase that belongs to the MAP kinase kinase family. The signal cascade mediated by this kinase is involved in growth factor-stimulated cell proliferation and muscle cell differentiation. 4 alternatively spliced human isoforms have been reported. Diseases associated with MAP2K5 include Caroli Disease and Restless Legs Syndrome. SNP rs1026732 in MAP2K5/SKOR1 was significantly associated with restless legs syndrome (RLS). RLS is considered a genetic disease and, following a genome-wide association study conducted in 2007, the MAP2K5 gene has been regarded as the promising candidate gene for RLS.
全称
mitogen-activated protein kinase kinase 5
Related Pathways
  • Death Receptor Signaling
    Death Receptor Signaling
  • VEGF Signaling Pathway
    VEGF Signaling Pathway
  • Actin Dynamics Signaling Pathway
    Actin Dynamics Signaling Pathway
  • B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway
  • G Protein-coupled Receptors Signaling
    G Protein-coupled Receptors Signaling
  • Jak-Stat Signaling Pathway
    Jak-Stat Signaling Pathway
  • Common G-Chain signaling pathway
    Common G-Chain signaling pathway
  • IL1 signaling pathway
    IL1 signaling pathway
  • IL17 signaling pathway
    IL17 signaling pathway
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