Reacts with: Human Predicted to React with:
Mouse, Rat (Species predicted to react based on 100% sequence homology)
A synthetic peptide corresponding to the N-terminus of the Human MAP2K5
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human MAP2K5, and purified by antigen affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-MEK5/MAP2K5 Antibody, Rabbit Polyclonal 图片
Immunofluorescence staining of MAP2K5 in HeLa cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-human MAP2K5 polyclonal antibody (1:1000) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to nucleus.
Immunochemical staining of human MAP2K5 in human skeletal muscle with rabbit polyclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of human MAP2K5 in human heart with rabbit polyclonal antibody (1:200, formalin-fixed paraffin embedded sections).
MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5, also known as MEK5) is a Protein Coding gene. The protein encoded by this gene is a dual-specificity protein kinase that belongs to the MAP kinase kinase family. The signal cascade mediated by this kinase is involved in growth factor-stimulated cell proliferation and muscle cell differentiation. 4 alternatively spliced human isoforms have been reported. Diseases associated with MAP2K5 include Caroli Disease and Restless Legs Syndrome. SNP rs1026732 in MAP2K5/SKOR1 was significantly associated with restless legs syndrome (RLS). RLS is considered a genetic disease and, following a genome-wide association study conducted in 2007, the MAP2K5 gene has been regarded as the promising candidate gene for RLS.