Anti-MUC1 Antibody, Rabbit Polyclonal

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Anti-MUC1 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-MUC1 Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Human
特异性
Human MUC1
免疫原
Recombinant Human MUC-1 / Mucin 1 / CD227 protein
制备方法
Produced in rabbits immunized with purified, recombinant Human MUC-1 / Mucin 1 / CD227 (rh MUC-1 / Mucin 1 / CD227;NP_001018016.1; Met1-Gly167). MUC-1 / Mucin 1 / CD227 specific IgG was purified by Human MUC-1 / Mucin 1 / CD227 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-MUC1 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:2500-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-MUC1 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of human MUC1 in human ovarian cancer with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human MUC1 in human breast carcinoma with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections).

Anti-MUC1 Antibody, Rabbit Polyclonal: 别称

Anti-ADMCKD Antibody; Anti-ADMCKD1 Antibody; Anti-CA15-3 Antibody; Anti-CD227 Antibody; Anti-EMA Antibody; Anti-H23AG Antibody; Anti-KL-6 Antibody; Anti-MAM6 Antibody; Anti-MCD Antibody; Anti-MCKD Antibody; Anti-MCKD1 Antibody; Anti-MUC-1 Antibody; Anti-MUC-1/SEC Antibody; Anti-MUC-1/X Antibody; Anti-MUC1/ZD Antibody; Anti-Mucin 1 Antibody; Anti-PEM Antibody; Anti-PEMT Antibody; Anti-PUM Antibody

MUC1 背景信息

Mucin 1, cell surface-associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach, and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized, and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC, and NF-kappa-B pathways. In the activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
全称
mucin 1, cell surface associated
研究领域
Related Pathways
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参考文献
  • Brayman M, et al. (2004) MUC1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol 2: 4.
  • Schroeder J A, et al. (2001) Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 276 (16): 13057-64.
  • Li Y, et al. (2001) The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 276 (38): 35239-42.
  • Use of CA15‑3 for screening breast cancer: An antibody‑lectin sandwich assay for detecting glycosylation of CA15‑3 in sera
    Author
    Choi, JW;Moon, BI;Lee, JW;Kim, HJ;Jin, Y;Kim, HJ;
    Year
    2018
    Journal
    Oncol. Rep.
    Application
    ELISA and IP (serum sample)
  • A three-dimensional A549 cell culture model to study respiratory syncytial virus infections
    Author
    Saleh, F;Harb, A;Soudani, N;Zaraket, H;
    Year
    2020
    Journal
    Journal of Infection and Public Health
    Application
    IF
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