Anti-NRG1 Beta 1 Antibody


Anti-NRG1 Beta 1 Antibody 产品信息

Anti-NRG1 Beta 1 Antibody
Reacts with: Human
Human Neuregulin-1
No cross-reactivity in WB with
Human NRG1-alpha
A synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1.
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, a synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG2b Clone #03
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-NRG1 Beta 1 Antibody 经验证的应用

应用 推荐稀释比/用量
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-NRG1 Beta 1 Antibody 图片

Anti-NRG1-beta 1 mouse monoclonal antibody at 1:500

Lane A: Human NRG1-beta1 (11609-H01H2) (100ng)

Lane B: Human NRG1-alpha (13499-H02H) (100ng)


Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution.

Performed under reducing conditions.

Anti-NRG1 Beta 1 Antibody: 别称

Anti-ARIA Antibody; Anti-GGF Antibody; Anti-GGF2 Antibody; Anti-HGL Antibody; Anti-HRG Antibody; Anti-HRG1 Antibody; Anti-HRGA Antibody; Anti-MST131 Antibody; Anti-MSTP131 Antibody; Anti-NDF Antibody; Anti-Neuregulin 1 Antibody; Anti-NRG1-IT2 Antibody; Anti-SMDF Antibody

Neuregulin-1 背景信息

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
neuregulin 1
  • Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
  • Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
  • Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
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