Recombinant Anti-PD-L2 Antibody (FITC), Rabbit Monoclonal

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Recombinant Anti-PD-L2 Antibody (FITC), Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-PD-L2 Antibody (FITC), Rabbit Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human PD-L2
免疫原
Recombinant Human B7-DC / PD-L2 / CD273 / PDCD1LG2 Protein (Catalog#10292-H08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human B7-DC / PD-L2 / CD273 / PDCD1LG2 (rh B7-DC / PD-L2 / CD273 / PDCD1LG2; Catalog#10292-H08H; NP_079515.2; Met1-Pro219) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
来源
Monoclonal Rabbit IgG Clone #002
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
FITC
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Recombinant Anti-PD-L2 Antibody (FITC), Rabbit Monoclonal 图片

Flow cytometric analysis of Human PDL2(CD273) expression on monocyte-derived dendritic cells. Cells were stained with FITC-conjugated anti-Human PDL2(CD273). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-PD-L2 Antibody (FITC), Rabbit Monoclonal: 别称

Anti-B7-DC Antibody; Anti-B7DC Antibody; Anti-bA574F11.2 Antibody; Anti-Btdc Antibody; Anti-CD273 Antibody; Anti-PD-L2 Antibody; Anti-PDCD1L2 Antibody; Anti-PDL2 Antibody

PD-L2 背景信息

Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
全称
programmed cell death 1 ligand 2
研究领域
参考文献
  • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
  • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
  • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.
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