Anti-L-selectin Antibody (APC), Mouse Monoclonal

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Anti-L-selectin Antibody (APC), Mouse Monoclonal 产品信息

产品名称
Anti-L-selectin Antibody (APC), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human L-selectin
免疫原
Recombinant Human CD62L / L-Selectin Protein (Catalog#11838-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD62L / L-Selectin (rh CD62L / L-Selectin; Catalog#11838-H08H; P14151-1; Met1-Asn332) and conjugated with APC under optimum conditions, the unreacted APC was removed.
来源
Monoclonal Mouse IgG1 Clone #01
纯化
Protein A
缓冲液
PBS solution containing 0.5% BSA and 0.09% sodium azide
偶联物
APC
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-L-selectin Antibody (APC), Mouse Monoclonal 图片

Flow cytometric analysis of Human SELL(CD62L) expression on human whole blood lymphocytes. Cells were stained with APC-conjugated anti-Human SELL(CD62L). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Anti-L-selectin Antibody (APC), Mouse Monoclonal: 别称

Anti-CD62L Antibody; Anti-LAM1 Antibody; Anti-LECAM1 Antibody; Anti-LEU8 Antibody; Anti-LNHR Antibody; Anti-LSEL Antibody; Anti-LYAM1 Antibody; Anti-PLNHR Antibody; Anti-TQ1 Antibody

L-selectin 背景信息

L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
全称
selectin L
参考文献
  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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