Anti-SPINK4 Antibody, Rabbit Polyclonal

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Anti-SPINK4 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-SPINK4 Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Human
特异性
Human SPINK4
免疫原
Recombinant Human SPINK4 protein (Catalog#11669-H08H)
制备方法
Produced in rabbits immunized with purified, recombinant Human SPINK4 (rh SPINK4; Catalog#11669-H08H; NP_055286.1; Met 1-Cys 86). SPINK4 specific IgG was purified by human SPINK4 affinity chromatography .
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-SPINK4 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-SPINK4 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of human SPINK4 in human skin with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human SPINK4 in human pancreas with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-SPINK4 Antibody, Rabbit Polyclonal: 别称

Anti-HEL136 Antibody; Anti-MGC133107 Antibody; Anti-PEC-60 Antibody; Anti-PEC60 Antibody; Anti-SPINK4 Antibody

SPINK4 背景信息

Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged infertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.
全称
serine peptidase inhibitor, Kazal type 4
参考文献
  • Schneider, A. et al., 2004,Gastroenterol Clin North Am. 33 (4): 789-806.
  • Wapenaar, MC. et al., 2007, Immunogenetics. 59 (5): 349-57.
  • Brattsand, M. et al., 2009, J Invest Dermatol. 129 (7): 1656-65.
  • Chen, T. et al., 2009, Proteins. 77 (1): 209-19.
  • Noah, TK. et al., 2010, Exp Cell Res. 316 (3): 452-65.
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