Recombinant Human SPINK4 protein (Catalog#11669-H08H)
Produced in rabbits immunized with purified, recombinant Human SPINK4 (rh SPINK4; Catalog#11669-H08H; NP_055286.1; Met 1-Cys 86). SPINK4 specific IgG was purified by human SPINK4 affinity chromatography
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-SPINK4 Antibody, Rabbit Polyclonal 经验证的应用
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-SPINK4 Antibody, Rabbit Polyclonal 图片
Immunochemical staining of human SPINK4 in human skin with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human SPINK4 in human pancreas with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged infertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.
serine peptidase inhibitor, Kazal type 4
Schneider, A. et al., 2004,Gastroenterol Clin North Am. 33 (4): 789-806.
Wapenaar, MC. et al., 2007, Immunogenetics. 59 (5): 349-57.
Brattsand, M. et al., 2009, J Invest Dermatol. 129 (7): 1656-65.