Anti-Transferrin Receptor/TFRC Antibody, Mouse Monoclonal

RRID Number: AB_2860268
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Anti-Transferrin Receptor/TFRC Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-Transferrin Receptor/TFRC Antibody, Mouse Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human Transferrin Receptor/TFRC
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
免疫原
Recombinant Human Transferrin Receptor / TFRC / CD71 protein (Catalog#11020-H07H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Transferrin Receptor / TFRC / CD71 (rh Transferrin Receptor / TFRC / CD71; Catalog#11020-H07H; AAA61153.1; Cys89-Phe 760). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG1 Clone #02
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Transferrin Receptor/TFRC Antibody, Mouse Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Transferrin Receptor/TFRC Antibody, Mouse Monoclonal: 别称

Anti-CD71 Antibody; Anti-p90 Antibody; Anti-T9 Antibody; Anti-TFR Antibody; Anti-TFR1 Antibody; Anti-TR Antibody; Anti-TRFR Antibody

Transferrin Receptor/TFRC 背景信息

Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
全称
transferrin receptor
参考文献
  • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
  • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
  • Tosoni D., et al., 2005, Cell 123:875-888.
  • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
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