Anti-TIE2 Antibody (APC), Mouse Monoclonal

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Anti-TIE2 Antibody (APC), Mouse Monoclonal 产品信息

产品名称
Anti-TIE2 Antibody (APC), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human TIE2
免疫原
Recombinant Human Tie2 / CD202b / TEK protein (Catalog#10700-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Tie2 / CD202b / TEK (rh Tie2 / CD202b / TEK; Catalog#10700-H08H; AAA61139.1; Met1-Lys745) and conjugated with APC under optimum conditions, the unreacted APC was removed.
来源
Monoclonal Mouse IgG1 Clone #07
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
APC
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-TIE2 Antibody (APC), Mouse Monoclonal 图片

Profile of anti-Human TIE2 (CD202b) reactivity on HUVEC cells analyzed by flow cytometry.

Anti-TIE2 Antibody (APC), Mouse Monoclonal: 别称

Anti-CD202B Antibody; Anti-TIE-2 Antibody; Anti-TIE2 Antibody; Anti-VMCM Antibody; Anti-VMCM1 Antibody

TIE2 背景信息

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
全称
TEK tyrosine kinase, endothelial
参考文献
  • Jones N, et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-108.
  • Sato A, et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-27.
  • Huang L, et al. (1995) GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK / TIE2 receptor tyrosine kinase. Oncogene. 11(10): 2097-103.
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