Anti-TIE2 Antibody, Rabbit Polyclonal

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Anti-TIE2 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-TIE2 Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Human
特异性
Human TIE2
免疫原
Recombinant Human TIE2 protein (Catalog#10700-H08H)
制备方法
Produced in rabbits immunized with purified, recombinant Human TIE2 (rh TIE2; Catalog#10700-H08H; AAA61139.1; Met 1-Lys 745). Total IgG was purified by Protein A affinity chromatography .
来源
Polyclonal Rabbit IgG
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TIE2 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TIE2 Antibody, Rabbit Polyclonal: 别称

Anti-CD202B Antibody; Anti-TIE-2 Antibody; Anti-TIE2 Antibody; Anti-VMCM Antibody; Anti-VMCM1 Antibody

TIE2 背景信息

TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
全称
TEK tyrosine kinase, endothelial
参考文献
  • Jones N, et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-108.
  • Sato A, et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-27.
  • Huang L, et al. (1995) GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK / TIE2 receptor tyrosine kinase. Oncogene. 11(10): 2097-103.
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