Anti-TRAIL/TNFSF10 Antibody, Mouse Monoclonal

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Anti-TRAIL/TNFSF10 Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-TRAIL/TNFSF10 Antibody, Mouse Monoclonal
经验证的应用
ELISA,ELISA(Cap)
交叉反应
Reacts with: Human
特异性
Human TRAIL/TNFSF10
免疫原
Recombinant Human TNFSF10 / TRAIL / APO-2L (CD253) Protein (Catalog#10409-HNAE)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNFSF10 / TRAIL / APO-2L (CD253) (rh TNFSF10 / TRAIL / APO-2L (CD253); Catalog#10409-HNAE; NP_003801.1; Val114-Gly281). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG1 Clone #03
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TRAIL/TNFSF10 Antibody, Mouse Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
ELISA(Cap) 1:250-1:2000
Notes
ELISA(Cap): This antibody will detect Human TRAIL/TNFSF10 in ELISA pair set (Catalog: # SEK10409). In a sandwich ELISA, it can be used as detection antibody.
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TRAIL/TNFSF10 Antibody, Mouse Monoclonal: 别称

Anti-Apo-2L Antibody; Anti-APO2L Antibody; Anti-CD253 Antibody; Anti-TL2 Antibody; Anti-TRAIL Antibody

TRAIL/TNFSF10 背景信息

Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
全称
tumor necrosis factor (ligand) superfamily, member 10
研究领域
Related Pathways
  • Death Receptor Signaling
    Death Receptor Signaling
  • p53 Pathway
    p53 Pathway
参考文献
  • Song C, et al. (2005) TRAIL (CD253), a new member of the TNF superfamily. J Biol Regul Homeost Agents. 19(1-2): 73-7.
  • Kuribayashi K, et al. (2008) TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death. Cancer Biol Ther. 7(12): 2034-8.
  • Wiley SR, et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 3(6): 673-82.
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