Anti-Vimentin Antibody, Rabbit Polyclonal

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Anti-Vimentin Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-Vimentin Antibody, Rabbit Polyclonal
经验证的应用
IHC-P
交叉反应
Reacts with: Human
特异性
Human Vimentin
免疫原
A synthetic peptide corresponding to the center region of the human Vimentin.
制备方法
Produced in rabbits immunized with A synthetic peptide corresponding to the center region of the human Vimentin., and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Vimentin Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Vimentin Antibody, Rabbit Polyclonal 图片

Immunochemical staining of human Vimentin in human malignant melanoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human Vimentin in human colon carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-Vimentin Antibody, Rabbit Polyclonal: 别称

Anti-CTRCT30 Antibody; Anti-HEL113 Antibody

Vimentin 背景信息

Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. Therefore, in general, it is accepted that vimentin is the cytoskeletal component responsible for maintaining cell integrity. Vimentin is also responsible for stabilizing cytoskeletal interactions. It is found that vimentin control the transport of low-density lipoprotein. It has been used as a sarcoma tumor marker to identify mesenchyme.
全称
vimentin
参考文献
  • Russell RL, et al. (2001) Uridine phosphorylase association with vimentin. Intracellular distribution and localization. J Biol Chem. 276(16):13302-7.
  • Moinova, et al. (2012) Aberrant Vimentin Methylation is Characteristic of Upper GI Pathologies. Cancer Epidemiology Biomarkers Prev. 21(4):594-600.
  • Leader M, et al. (1987) Vimentin: an evaluation of its role as a tumour marker. Histopathology. 11(1):63-72.
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