Anti-IFNAR2 Antibody (PE), Mouse Monoclonal

RRID Number: AB_2860149
1/1
Price:
Size:
Number:

Anti-IFNAR2 Antibody (PE), Mouse Monoclonal 产品信息

产品名称
Anti-IFNAR2 Antibody (PE), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human IFNAR2
免疫原
Recombinant Human IFNAR2 protein (Catalog#10359-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFNAR2 (rh IFNAR2; Catalog#10359-H08H; NP_997468.1; Met 1-Lys 243) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Mouse IgG1 Clone #07
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
偶联物
PE
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-IFNAR2 Antibody (PE), Mouse Monoclonal 图片

Profile of anti-IFNAR2 reactivity on Jurkat cells analyzed by flow cytometry.

Anti-IFNAR2 Antibody (PE), Mouse Monoclonal: 别称

Anti-IFN-alpha-REC Antibody; Anti-IFN-R Antibody; Anti-IFNABR Antibody; Anti-IFNARB Antibody

IFNAR2 背景信息

Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNα therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNα therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface.
全称
interferon (alpha, beta and omega) receptor 2
参考文献
  • Ito K, et al. (2004) Initial expression of interferon alpha receptor 2 (IFNAR2) on CD34-positive cells and its down-regulation correlate with clinical response to interferon therapy in chronic myelogenous leukemia. Eur J Haematol. 73(3): 191-205.
  • Kim SH, et al. (1997) Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2. Gene. 196(1-2): 279-86.
  • Saleh AZ, et al. (2004) Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor. Oncogene. 23(42): 7076-86.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后 U.S.A.