Anti-IL3RA Antibody (PE), Mouse Monoclonal

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Anti-IL3RA Antibody (PE), Mouse Monoclonal 产品信息

产品名称
Anti-IL3RA Antibody (PE), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Human
特异性
Human IL3RA
免疫原
Recombinant Human IL3RA / CD123 Protein (Catalog#10518-H08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL3RA / CD123 (rh IL3RA / CD123; Catalog#10518-H08H; NP_002174.1; Met1-Arg305) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Mouse IgG2b Clone #57
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
偶联物
PE
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-IL3RA Antibody (PE), Mouse Monoclonal 图片

Flow cytometric analysis of Human IL13RA1 expression on KG-1 cells. Cells were stained with PE-conjugated anti-Human IL13RA1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-IL3RA Antibody (PE), Mouse Monoclonal: 别称

Anti-CD123 Antibody; Anti-hIL-3Ra Antibody; Anti-IL3R Antibody; Anti-IL3RAY Antibody; Anti-IL3RX Antibody; Anti-IL3RY Antibody

IL3RA 背景信息

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and/or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.
全称
interleukin 3 receptor, alpha (low affinity)
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参考文献
  • Del Giudice I, et al. (2004) The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 89(3): 303-8.
  • Du X, et al. (2007) New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. J Immunother. 30(6): 607-13.
  • Yue LZ, et al. (2010) Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome. Chin Med J (Engl). 123(15): 2034-2037.
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