Recombinant Anti-CD13 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CD13 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-CD13 Antibody, Rabbit Monoclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Mouse
特异性
Mouse CD13
No cross-reactivity in ELISA with
Human ANPEP / CD13
免疫原
Recombinant Mouse ANPEP protein (Catalog#50001-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse ANPEP metalloprotease domain (rM ANPEP; Catalog#50001-M08H; Lys 66-Ser 966; NP_032512.2).
来源
Monoclonal Rabbit IgG Clone #101
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CD13 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CD13 Antibody, Rabbit Monoclonal 图片

Immunochemical staining of mouse ANPEP in mouse kidney with Rabbit Monoclonal Antibody (1:300, formalin-fixed paraffin embedded sections).
Immunochemical staining of mouse ANPEP in mouse intestines with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections).

Recombinant Anti-CD13 Antibody, Rabbit Monoclonal: 别称

Anti-AP-M Antibody; Anti-AP-N Antibody; Anti-Apn Antibody; Anti-Cd13 Antibody; Anti-P150 Antibody

CD13 背景信息

Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas.
全称
alanyl (membrane) aminopeptidase
参考文献
  • Pasqualini R, et al. (2000) Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.Cancer Res. 60(3): 722-7.
  • Mabjeesh SJ, et al. (2005) Aminopeptidase N gene expression and abundance in caprine mammary gland is influenced by circulating plasma peptide. J Dairy Sci. 88(6): 2055-64.
  • Dunkel B, et al. (2009) Neutrophil and platelet activation in equine recurrent airway obstruction is associated with increased neutrophil CD13 expression, but not platelet CD41/61 and CD62P or neutrophil-platelet aggregate formation. Vet Immunol Immunopathol. 131(1-2): 25-32.
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