Anti-CD131 Antibody, Rabbit Polyclonal

1/1
Price:
Size:
Number:

Anti-CD131 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-CD131 Antibody, Rabbit Polyclonal
经验证的应用
IHC-P
交叉反应
Reacts with: Mouse
特异性
Mouse CD131
免疫原
A synthetic peptide corresponding to the center region of the Mouse CD131 / CSF2RB / IL3RB / IL5RB
制备方法
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse CD131 / CSF2RB / IL3RB / IL5RB, and purified by antigen affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD131 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:250-1:1000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD131 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of human CSF2RB in human ovarian cancer with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections).

Anti-CD131 Antibody, Rabbit Polyclonal: 别称

Anti-AI848964 Antibody; Anti-AIC2B Antibody; Anti-Bc Antibody; Anti-CDw131 Antibody; Anti-Csf2rb1 Antibody; Anti-Csfgmrb Antibody; Anti-Il3r Antibody; Anti-Il3rb Antibody; Anti-Il3rb1 Antibody; Anti-Il5rb Antibody

CD131 背景信息

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
全称
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
参考文献
  • Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
  • Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
  • Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后 U.S.A.