Recombinant Anti-CD204/MSR1 Antibody, Rabbit Monoclonal

RRID Number: AB_2860488
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CD204/MSR1 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-CD204/MSR1 Antibody, Rabbit Monoclonal
经验证的应用
IHC-P,FCM,ICC/IF
交叉反应
Reacts with: Mouse
特异性
Mouse CD204/MSR1
免疫原
Recombinant Mouse MSR1 / CD204 protein (Catalog#50129-M07H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse MSR1 / CD204 (rM MSR1 / CD204; Catalog#50129-M07H; AAH03814.1; Trp 83-Val 354).
来源
Monoclonal Rabbit IgG Clone #004
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CD204/MSR1 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:50-1:200
ICC-IF 1:50-1:1000
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CD204/MSR1 Antibody, Rabbit Monoclonal 图片

Confocal immunofluorescence analysis of Mouse MSR1 in RAW264.7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Mouse MSR1 monoclonal antibody (1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to plasma membrane.
Immunochemical staining of mouse MSR1 in mouse liver with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).
Flow cytometric analysis of Mouse MSR1(CD204) expression on Raw264.7 cells. Cells were stained with purified anti-Mouse MSR1(CD204), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-CD204/MSR1 Antibody, Rabbit Monoclonal: 别称

Anti-MRS-A Antibody; Anti-MSR Antibody; Anti-MSR-A Antibody; Anti-Scara1 Antibody; Anti-Scvr Antibody; Anti-SR-AI Antibody; Anti-SR-AII Antibody

CD204/MSR1 背景信息

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low-density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.
全称
macrophage scavenger receptor 1
参考文献
  • Wang L. et al., 2003, Nat Genet. 35 (2): 128-9.
  • Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3.
  • Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103.
  • Sun J. et al., 2006, Prostate. 66 (7): 728-37.
  • Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
    Author
    Kamata, T;So, TY;Ahmed, Q;Giblett, S;Patel, B;Luo, J;Reddel, R;Pritchard, C;
    Year
    2020
    Journal
    Cell Rep
    Application
    IHC
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