Mouse CD27 No cross-reactivity in ELISA with Human CD27 Human TNFRSF8 Human CD40 Human DR6 Human TNFRSF10D Mouse HVEM Mouse FAS Mouse TNFRSF10b Human 4-1BB Human TNFRI Human TNFRII Human RELT Human FAS
Recombinant Mouse CD27 protein (Catalog#50110-M08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD27 (rM CD27; Catalog#50110-M08H; NP_001028298.1; Met 1-Arg 182).
Monoclonal Rabbit IgG Clone #133
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.