Recombinant Anti-CD27 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CD27 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-CD27 Antibody, Rabbit Monoclonal
经验证的应用
IHC-P
交叉反应
Reacts with: Mouse
特异性
Mouse CD27
免疫原
Recombinant Mouse CD27/TNFRSF7 Protein (Catalog#50110-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD27/TNFRSF7 (rM CD27/TNFRSF7; Catalog#50110-M08H; NP_001028298.1; Met1-Arg182).
来源
Monoclonal Rabbit IgG Clone #618
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CD27 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CD27 Antibody, Rabbit Monoclonal 图片

Immunochemical staining of mouse CD27 in mouse spleen with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
Immunochemical staining of mouse CD27 in mouse thymus with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.

Recombinant Anti-CD27 Antibody, Rabbit Monoclonal: 别称

Anti-S152 Antibody; Anti-Tnfrsf7 Antibody; Anti-Tp55 Antibody

CD27 背景信息

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.
全称
CD27 molecule
研究领域
参考文献
  • Drner T, et al. (2004) Correlation of circulating CD27 high plasma cells and disease activity in systemic lupus erythematosus. Lupus. 13(5): 283-9.
  • Sahota SS, et al. (2009) CD27 in defining memory B-cell origins in Waldenstrm's macroglobulinemia. Clin Lymphoma Myeloma. 9(1): 33-5.
  • Jiang J, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol. 30(4): 566-73.
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