Anti-CD38 Antibody, Rabbit Polyclonal

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Anti-CD38 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-CD38 Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P,FCM
交叉反应
Reacts with: Mouse
Not React with: Human
特异性
Mouse CD38
免疫原
Recombinant Mouse CD38 protein (Catalog#50191-M08H)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse CD38 (rM CD38; Catalog#50191-M08H; NP_031672.2; Leu 45-Thr 304). CD38 specific IgG was purified by mouse CD38 affinity chromatography .
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CD38 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
IHC-P 1:2500-1:10000
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CD38 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of mouse CD38 in mouse kidney with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). Positive staining was localized to endotheliocyte.
Immunochemical staining of mouse CD38 in mouse heart with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). Positive staining was localized to endotheliocyte.
Flow cytometric analysis of CD38 expression on spleen lymphocytes. BALB/c splenocytes were stained with Mouse CD38 Affinity Purified Polyclonal Ab (50191-RP02), then a FITC-conjugated second step antibody. The histogram were derived from the gated events based on light scattering characteristics of lymphocytes.

Anti-CD38 Antibody, Rabbit Polyclonal: 别称

Anti-ADPRC 1-rs1 Antibody; Anti-ADPRC1 Antibody; Anti-Cd38 Antibody; Anti-Cd38-rs1 Antibody; Anti-I-19 Antibody

CD38 背景信息

The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.
全称
CD38 molecule
研究领域
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
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